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  • Self-assembling paclitaxel-mediated stimulation of tumor-associated . . .
    Here, we report on a self-assembling paclitaxel (PTX) filament (PF) hydrogel that stimulates macrophage-mediated immune response for local treatment of recurrent glioblastoma
  • Self-assembling paclitaxel-mediated stimulation of tumor-associated . . .
    In this context, we convert paclitaxel (PTX), a small-molecule anticancer drug of poor water solubility, into a molecular hydrogelator that can be used for local delivery of aCD47, a hydrophilic macromolecular antibody
  • Self-assembling paclitaxel-mediated stimulation of tumor-associated . . .
    Here, we report on a self-assembling paclitaxel (PTX) filament (PF) hydrogel that stimulates macrophage-mediated immune response for local treatment of recurrent glioblastoma
  • Self-assembling paclitaxel-mediated stimulation of tumor . . .
    Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma Proceedings of the National Academy of Sciences of the United States of America ( IF 9 1 ) Pub Date : 2023-04-25 , DOI: 10 1073 pnas 2204621120
  • PNAS | 诱导巨噬细胞吞噬癌细胞，获100%存活率 - 知乎
    约翰霍普金斯大学的一个研究小组开发了一种“drug-delivered-by-drug”水凝胶，将抗癌药物 紫杉醇 （PTX）和抗CD47抗体（aCD47）结合在一种溶液中，自组装成抗癌凝胶，填充脑肿瘤手术切除后留下的微小凹槽。 活体小鼠的试验表明，化学免疫疗法aCD47 PF水凝胶抑制了肿瘤切除后的肿瘤复发，导致研究人员所说的“惊人的100% 存活率 ”。 他们认为，这一结果为被诊断为 胶质母细胞瘤 的患者带来了希望，胶质母细胞瘤是人类最致命、最常见的脑肿瘤之一。 由约翰霍普金斯大学化学和 生物分子 工程师Honggang Cui博士领导的科学家们认为，这种凝胶还可以到达手术中可能遗漏的区域，而目前的药物可能无法到达这些区域，以杀死剩余的癌细胞并抑制 肿瘤生长。
  • Self-assembling paclitaxel-mediated stimulation of tumor-associated . . .
    Here, we report on a self-assembling paclitaxel (PTX) filament (PF) hydrogel that stimulates macrophage-mediated immune response for local treatment of recurrent glioblastoma
  • Self-Assembling Chemoimmunotherapy Hydrogel Treats 100% of Glioblastoma . . .
    Hydrogel provides localized, sustained release of PTX and aCD47 into post-surgical cavity, preventing tumor recurrence and triggering immunological memory
  • Self-assembling paclitaxel-mediated stimulation of tumor-associated . . .
    Here, we report on a self-assembling paclitaxel (PTX) filament (PF) hydrogel that stimulates macrophage-mediated immune response for local treatment of recurrent glioblastoma
  • PNAS惊人成果：一种凝胶竟然能阻止脑瘤？ - 生物通
    Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma 一种新型凝胶药物治愈了100%患有侵袭性脑癌的小鼠，这一惊人的结果为被诊断患有胶质母细胞瘤的患者带来了新的希望。 胶质母细胞瘤是人类最致命、最常见的脑肿瘤之一。
  • Self-assembling paclitaxel-mediated stimulation of tumor . . .
    Article "Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma" Detailed information of the J-GLOBAL is an information service managed by the Japan Science and Technology Agency (hereinafter referred to as "JST")





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